The fourth-generation Lexus GS (L10) launched in the UK in early 2012. A facelift in 2015 (for the 2016 model year) brought updated headlights, a new grille design, improved infotainment, and the introduction of Lexus Safety System+. UK sales ended around 2018 as the GS was phased out in favour of the ES.

The GS L10 featured a large 12.3-inch multimedia display on the Gen7 System, with integrated sat-nav, DAB digital radio, Bluetooth, and USB connectivity. Entry-level models had a 12-speaker Pioneer system, while top-spec trims like F Sport and Premier offered the acclaimed Mark Levinson Premium Surround Sound with 17 speakers and deep, high-fidelity audio performance.