The R172 is the third and final generation of the SLK-Class, produced from 2011 to 2020. It introduced a more muscular, upscale look, improved dynamics, and modern tech, while continuing the signature Vario-Roof retractable hardtop formula. In 2016, it received a facelift and name change to "SLC", aligning with Mercedes-Benz’s new naming system.

The SLK up until the facelift, is on the Mercedes NTG4.5 infotainment system.