The Mercedes-Benz Sprinter Mk3 (W907/W910) was launched in 2018, marking the third generation of the Sprinter van. It represented a significant leap in design, connectivity, and driver assistance technologies. Unlike its predecessor (W906), the Mk3 was developed independently by Mercedes-Benz, ending the previous partnership with Volkswagen.

A facelift arrived in 2023, where the vehicle moved over to the new MBUX 2G NTG7.0 system.

Pre-facelift models had 3 different stock options: the basic radio or the MBUX NTG6.0 system with either the 7" screen option or the 10.25" screen option.