The second generation Zafira, internally designated Zafira B, debuted in Europe on 12 February 2005, with sales starting on 9 June 2005. It shared the platform and mechanical parts with the Vauxhall Astra H (Mk4).

Although this generation was replaced in the end of 2011 by the Zafira C, this model remained in production until May 2014 as the Zafira Family. 

The factory wiring uses a Quadlock plug and Fakra antenna lead.